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Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
Francisco Arriagada1, Olosmira Correa1, Germán Günther2
1Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone, 1007, Independencia, Santiago, Chile.
Abstract:
Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.
Insights
Morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) enhance antioxidant properties. These nanoantioxidants effectively scavenge hydroxyl radicals and quench singlet oxygen, showing improved stability and synergistic effects.
Area of Science:
- Materials Science
- Nanotechnology
- Biochemistry
Background:
- Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with significant health benefits.
- Poor water solubility and environmental sensitivity limit morin's pharmaceutical and cosmetic applications.
Purpose of the Study:
- To synthesize morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as a potential nanoantioxidant.
- To characterize the adsorption kinetics, isotherm, and antioxidant capacity of AMSNPs-MOR.
Main Methods:
- Synthesis of morin-modified mesoporous silica nanoparticles.
- Adsorption kinetics and isotherm studies using Langmuir, Freundlich, and Temkin models.
- Evaluation of antioxidant capacity as a hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher.
Main Results:
- Adsorption data fitted well with pseudo-second order kinetics and isotherm models.
- AMSNPs-MOR demonstrated effective scavenging of hydroxyl radicals and quenching of singlet oxygen.
- A synergistic antioxidant effect was observed between AMSNPs-MOR and morin, increasing with adsorbed morin.
Conclusions:
- AMSNPs-MOR represent a promising nanoantioxidant material with improved properties compared to free morin.
- The developed nanoparticles offer enhanced stability and bioavailability for morin.
- The synergistic antioxidant activity highlights the potential of AMSNPs-MOR in pharmaceutical and cosmetic applications.
