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Related Experiment Videos

Corticosteroid modulation of hippocampal potentials: increased effect with aging.

D S Kerr1, L W Campbell, S Y Hao

  • 1Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC 27103.

Science (New York, N.Y.)
|September 29, 1989
PubMed
Summary

Adrenal steroids, like corticosterone, influence hippocampal neuron function by modulating calcium conductance. This effect is amplified in aged rats, potentially explaining glucocorticoid involvement in brain aging.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Adrenal steroids bind to hippocampal neurons, potentially contributing to age-related cell loss.
  • Neurophysiological mechanisms linking adrenal steroids to hippocampal function remain unclear.

Purpose of the Study:

  • To investigate how adrenal steroids modulate hippocampal pyramidal cell membrane conductance.
  • To elucidate the role of corticosteroids in calcium-mediated processes in the aging brain.

Main Methods:

  • Electrophysiological recordings in hippocampal slices from young and aged adrenalectomized rats.
  • In vivo and in vitro administration of corticosterone.

Main Results:

  • Adrenalectomy reduced calcium-dependent slow afterhyperpolarization and calcium action potentials in hippocampal pyramidal cells.

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  • Corticosterone administration reversed these effects.
  • The reduction in afterhyperpolarization due to adrenalectomy was more pronounced in aged rats.

    • Conclusions:

    • Corticosteroids modulate calcium conductance in hippocampal neurons, impacting neuronal excitability.
    • Aging enhances the sensitivity of calcium-mediated processes to corticosteroids.
    • These findings offer insights into glucocorticoid roles in brain aging and neuronal function.