Design of Wireframe DNA Nanostructures-DNA Gridiron

Self-assembling nucleic acid molecules have shown merit as versatile materials for organizing and constructing nanoscale structures with both 2D and 3D geometries. This chapter focuses on strategies in designing DNA gridiron nanostructures based on four-arm junction. This design strategies aims at controlling DNA self-assembly with a higher degree of spatial precision by depicting arbitrary 3D geometries with their wireframe outlines using DNA helices (for edges) and four-arm junctions (for vertices).