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An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
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Fluzone® High-Dose Influenza Vaccine.
Corwin A Robertson1, Carlos A DiazGranados1, Michael D Decker1,2
1a Sanofi Pasteur Inc. , Swiftwater , PA , USA.
Expert Review of Vaccines
|November 5, 2016
Summary
Fluzone® High-Dose (IIV3-HD) offers superior protection against influenza in older adults compared to standard-dose vaccines. This enhanced influenza vaccine is immunogenic, safe, effective, and cost-effective for this population.
Area of Science:
- Immunology and Vaccinology
- Public Health
- Health Economics
Background:
- Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine designed for adults aged 65 years and older.
- IIV3-HD contains 60 µg of hemagglutinin per strain, four times the amount in standard-dose vaccines like Fluzone (IIV3-SD).
- It has been licensed for use in older adults in the US since 2009 and Canada since 2016.
Purpose of the Study:
- To review postlicensure studies on the immunogenicity, safety, and effectiveness of IIV3-HD in older adults.
- To summarize cost-effectiveness estimates for IIV3-HD in this demographic.
- To discuss potential uses of IIV3-HD in adults aged 50-64 and in individuals with poor responses to standard influenza vaccines.
Main Methods:
- Review of multiple postlicensure studies conducted since 2004.
- Analysis of data on antibody responses, protection against influenza, and influenza-associated hospitalizations.
- Evaluation of health economic analyses comparing IIV3-HD with standard-dose influenza vaccines.
Main Results:
- Consistent evidence shows IIV3-HD induces significantly greater antibody responses in older adults compared to IIV3-SD.
- IIV3-HD demonstrates better protection against influenza and influenza-associated hospitalizations than IIV3-SD in older adults.
- Health economic analyses indicate IIV3-HD is a cost-effective, and potentially cost-saving, alternative to standard-dose vaccines for older adults.
Conclusions:
- Fluzone® High-Dose (IIV3-HD) is a highly immunogenic, safe, and effective influenza vaccine for older adults, offering improved protection over standard-dose vaccines.
- IIV3-HD presents a favorable cost-effectiveness profile for influenza vaccination in the elderly population.
- Further research into IIV3-HD for immunocompromised individuals is warranted to assess its potential for enhancing immune responses and protection.
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