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Updated: Mar 12, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Baicalin, a natural LSD1 inhibitor
Yi-Chao Zheng1, Dan-Dan Shen1, Meng Ren1
1Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, PR China.
Abstract:
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory effect in cells. Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.
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