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Prognostic factors in C9orf72 amyotrophic lateral sclerosis

José Manuel Matamala1, Thanuja Dharmadasa1, Matthew C Kiernan1

  • 1Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 6, 2016
PubMed
Abstract

No abstract available in PubMed .

Keywords:
ALS

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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