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CLA Has a Useful Effect on Bone Markers in Patients with Rheumatoid Arthritis
N Aryaeian1, F Shahram2, M Djalali3
1Research Center for Environmental Health Technology, Iran University of Medical Sciences and Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Lipids
|November 6, 2016
Summary
Conjugated linoleic acid (CLA) supplementation showed significant positive effects on key bone markers, including telopeptides C, osteocalcin, and IGF1, in patients with rheumatoid arthritis. Further research is needed to confirm its long-term impact on bone health.
Area of Science:
- Rheumatology
- Immunology
- Nutritional Science
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with an increased risk of osteoporosis.
- Understanding factors influencing bone metabolism in RA is crucial for disease management.
Purpose of the Study:
- To investigate the effect of conjugated linoleic acid (CLA) on specific bone markers in patients with active rheumatoid arthritis.
- To evaluate CLA's potential role in mitigating bone loss associated with RA.
Main Methods:
- A randomized, double-blind clinical trial involving 52 RA patients.
- Intervention group received standard RA treatment plus CLA; control group received standard treatment plus placebo.
- Analysis of bone markers (telopeptides C, osteocalcin, IGF1, ALK-P), PGE2, and MMP3 using ELISA and other immunoassays.
Main Results:
- Significant improvements were observed in telopeptides C, osteocalcin, and IGF1 levels in the CLA group compared to placebo (P < 0.05).
- No significant differences were found between groups for ALK-P, PGE2, or MMP3.
- CLA demonstrated a potentially beneficial effect on specific bone metabolism indicators in RA patients.
Conclusions:
- Conjugated linoleic acid (CLA) may positively influence bone markers in rheumatoid arthritis patients.
- Longer-term studies evaluating bone mineral density are recommended to confirm CLA's efficacy for bone health in RA and other autoimmune bone diseases.
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