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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Reliable exclusion of prognostically significant coronary disease in left ventricular dysfunction by cardiac MRI

A C M Thompson1, J G Crilley2, D W Wilson3

  • 1Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, County Durham, UK; School of Medicine, Pharmacy and Health, Durham University, Queen's Campus, University Boulevard, Stockton-on-Tees, UK.

Clinical Radiology
|November 7, 2016
PubMed

Insights

Cardiac magnetic resonance (CMR) reliably excludes prognostically significant coronary artery disease (CAD) in patients with left ventricular systolic dysfunction (LVSD). Absence of subendocardial late gadolinium enhancement (LGE) indicates no significant CAD.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Left ventricular systolic dysfunction (LVSD) is associated with increased risk of coronary artery disease (CAD).
  • Accurate risk stratification is crucial for managing patients with LVSD.

Purpose of the Study:

  • To evaluate the diagnostic performance of cardiac magnetic resonance (CMR) in excluding prognostically significant CAD in patients with LVSD.
  • To determine if subendocardial late gadolinium enhancement (LGE) on CMR can rule out significant CAD.

Main Methods:

  • Retrospective analysis of 116 patients with LVSD who underwent both X-ray angiography and CMR.
  • Assessment of subendocardial LGE using the 17-segment model on CMR.
  • Definition of significant CAD based on coronary angiography criteria.

Main Results:

  • The study included 116 patients (mean age 64, 78% male) with a mean LVEF of 40%.
  • Prognostically significant CAD was present in 47% of patients.
  • Subendocardial LGE detected significant CAD with 100% sensitivity and no false negatives.

Conclusions:

  • The absence of subendocardial LGE on CMR effectively excludes prognostically significant CAD in patients with LVSD.
  • CMR is a valuable tool for ruling out significant CAD in this patient population.
Abstract

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