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Updated: Mar 12, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Discovery of a potent and highly specific β2 proteasome inhibitor from a library of copper complexes
Tongliang Zhou1, Yuanbo Cai2, Lei Liang1
1Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Abstract:
We reported the synthesis, characterization and biological activity of several copper(II) Schiff base complexes, which exhibit high proteasome inhibitory activities with particular selectivity of β2 subunit. Structure-activity relationships information obtained from complex Na2[Cu(a4s1)] demonstrated that distinct bonding modes in β2 and β5 subunits determines its selectivity and potent inhibition for β2 subunit.
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