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Updated: Mar 12, 2026
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
Published on: March 6, 2012
Antitumor efficacy of combined gene and radiotherapy in animals
O A Bezborodova1, E R Nemtsova2, A R Gevorkov2
1National Medical Research Radiological Center (NMRRC), Ministry of Healthcare of the Russian Federation, Obninsk, Kaluga oblast, Russia. olgabezborodova@yandex.ru.
Abstract:
Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1-mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1-mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed.
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