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Signaling targets of alcoholic intoxication in human skeletal muscle

T M Mirzoev1, Y N Lomonosova1, O E Zinovyeva2

  • 1Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia.

Doklady. Biochemistry and Biophysics
|November 7, 2016
PubMed

Insights

Early alcohol addiction in men does not cause muscle fiber loss but reduces insulin-like growth factor 1 (IGF-1) and protein synthesis signaling in skeletal muscle.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Sports Medicine

Background:

  • Alcohol addiction is a global health issue with significant systemic effects.
  • Skeletal muscle is metabolically active and can be affected by chronic alcohol exposure.
  • Understanding early molecular changes in skeletal muscle is crucial for timely intervention.

Purpose of the Study:

  • To investigate intracellular signaling pathways in skeletal muscle during early alcohol addiction.
  • To assess muscle fiber integrity and protein metabolism markers.
  • To determine the impact of early alcohol addiction on insulin-like growth factor 1 (IGF-1) levels.

Main Methods:

  • Analysis of skeletal muscle biopsy samples (m. vastus lateralis) from male patients.
  • Assessment of muscle fiber atrophy.
  • Measurement of signaling pathway markers for protein synthesis and degradation.
  • Quantification of plasma IGF-1 concentration.

Main Results:

  • No muscle fiber atrophy was observed in the vastus lateralis.
  • No significant alterations in signaling pathways controlling protein degradation were found.
  • A significant reduction in plasma IGF-1 and markers of protein synthesis signaling pathways was detected.

Conclusions:

  • Early stages of alcohol addiction in men do not induce skeletal muscle atrophy or affect protein degradation pathways.
  • Reduced IGF-1 and impaired protein synthesis signaling are early molecular consequences of alcohol addiction in skeletal muscle.

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