Related Experiment Video
Updated: Mar 12, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
Published on: December 17, 2013
Reprogramming Enhancers in Somatic Cell Nuclear Transfer, iPSC Technology, and Direct Conversion
Daekee Kwon1, Minjun Ji1, Seunghee Lee1
1Stem Cells and Regenerative Bioengineering Institute in Kangstem Biotech, Biomedical Science Building, #81 Seoul National University, Seoul, 08826, South Korea.
Direct cell fate conversion offers promise for regenerative medicine but faces challenges with efficiency and reproducibility. This review categorizes reprogramming enhancers to guide overcoming these obstacles in direct conversion technology.
Area of Science:
- Cellular reprogramming
- Regenerative medicine
- Biotechnology
Background:
- Direct cell fate conversion is a key technology for regenerative medicine.
- Low reprogramming efficiency and reproducibility hinder clinical translation.
- Existing reprogramming methods include somatic cell nuclear transfer and induced pluripotent stem cell technology.
Purpose of the Study:
- To review and categorize reprogramming enhancers.
- To identify strategies for improving direct conversion efficiency and reproducibility.
- To provide a practical plan for advancing direct conversion technology.
Main Methods:
- Literature review of reprogramming enhancers.
- Categorization of enhancers based on function.
- Analysis of enhancer roles in somatic cell nuclear transfer, induced pluripotent stem cell technology, and direct conversion.
Main Results:
- Identified and classified major reprogramming enhancers.
- Detailed the functional roles of enhancers across different reprogramming strategies.
- Highlighted enhancers with potential to improve direct conversion outcomes.
Conclusions:
- Reprogramming enhancers are crucial for advancing direct cell fate conversion.
- Strategic application of enhancers can overcome efficiency and reproducibility limitations.
- This review provides a framework for developing more robust direct conversion protocols.
More Related Videos
11:38RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
Published on: November 26, 2018
10:52Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
Published on: January 19, 2020
Related Concept Videos
Methods of Nuclear Reprogramming
Somatic to iPS Cell Reprogramming
Introduction to Nuclear Reprogramming
Induced Pluripotent Stem Cells
Somatic...
Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells