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[Clinical features of children with incomplete Kawasaki disease]

Chang Peng1, Yue-Jing Luo, Qian-Lu Xing

  • 1Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, China. pengchang_2006@126.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 8, 2016
PubMed

Insights

Incomplete Kawasaki disease (IKD) presents with atypical symptoms in children. Liver function tests, serum hyponatremia, and IL-6 levels may aid in early IKD diagnosis, despite a higher risk of coronary artery lesions.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Infectious Diseases

Background:

  • Kawasaki disease (KD) is a leading cause of acquired heart disease in children.
  • Incomplete Kawasaki disease (IKD) presents with fewer than the classic diagnostic criteria, posing diagnostic challenges.

Purpose of the Study:

  • To delineate the clinical characteristics of IKD in children.
  • To establish diagnostic references for early IKD detection.

Main Methods:

  • Retrospective analysis of clinical data from 22 children with IKD.
  • Comparison with 63 children diagnosed with KD and 20 febrile children as controls.
  • Statistical analysis of clinical and laboratory findings.

Main Results:

  • All children presented with pyrexia.
  • IKD group showed fewer limb changes, conjunctival hyperemia, and cervical lymphadenectasis compared to KD.
  • IKD group had elevated glutamic-pyruvic transaminase, but lower albumin, serum sodium, and IL-6 levels.
  • IKD group exhibited a higher incidence of coronary artery lesions than the KD group.

Conclusions:

  • Clinical presentation of IKD is often atypical.
  • Liver function tests, serum hyponatremia, and IL-6 levels are potential biomarkers for diagnosing IKD.
  • Early diagnosis of IKD is crucial due to increased risk of coronary artery lesions.
Abstract

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