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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Hypoxia01:23

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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[Long non-coding RNAs and hypoxic-ischemic brain damage].

Feng-Yan Zhao1, Yi Qu

  • 1Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China. mudz@scu.edu.cn.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 8, 2016
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate gene expression and are crucial in neural development. This review examines their specific roles in hypoxic-ischemic brain damage, highlighting their involvement in disease pathogenesis.

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not encode proteins.
  • lncRNAs play regulatory roles in various biological processes by interacting with DNA, mRNA, and proteins.
  • lncRNAs are implicated in neural development and the mechanisms underlying various diseases.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in the context of hypoxic-ischemic brain damage.
  • To consolidate current understanding of lncRNA involvement in the pathogenesis of brain injury due to hypoxia and ischemia.

Main Methods:

  • Literature review of existing studies on lncRNAs and hypoxic-ischemic brain damage.
  • Analysis of reported mechanisms by which lncRNAs regulate gene expression in the brain.
  • Synthesis of findings related to lncRNA function in neural development and disease pathology.

Main Results:

  • lncRNAs are key regulators of gene expression involved in cellular responses to hypoxia and ischemia.
  • Specific lncRNAs have been identified that modulate pathways critical to neuronal survival and brain damage.
  • Dysregulation of lncRNAs contributes to the pathogenesis of hypoxic-ischemic brain injury.

Conclusions:

  • lncRNAs represent a significant class of molecules involved in the complex pathophysiology of hypoxic-ischemic brain damage.
  • Further research into lncRNA functions may reveal novel therapeutic targets for treating brain injuries.