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Related Experiment Video

Updated: Mar 12, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

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Published on: December 2, 2014

Racial Differences in Aortic Stiffness in Children.

Wesley K Lefferts¹, Jacqueline A Augustine¹, Nicole L Spartano¹

¹Department of Exercise Science, Syracuse University, Syracuse, NY.

The Journal of Pediatrics

|November 8, 2016

Summary

Racial disparities in aortic stiffness and vascular markers of cardiovascular disease are evident in children. These differences in subclinical cardiovascular disease appear earlier than previously understood.

Keywords:

arterial stiffness central blood pressure pediatrics race

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Area of Science:

Pediatric cardiovascular health
Racial disparities in health outcomes
Vascular biology in children

Background:

Atherosclerotic cardiovascular disease (ASCVD) risk factors can manifest in childhood.
Understanding racial differences in early markers of ASCVD is crucial for targeted interventions.
Subclinical markers of vascular health in children require further investigation across diverse populations.

Purpose of the Study:

To investigate racial differences in central blood pressure and vascular structure/function.
To identify subclinical markers of atherosclerotic cardiovascular disease in children.
To explore early indicators of cardiovascular risk in African American versus white children.

Main Methods:

Cross-sectional study of 54 African American and 54 white children (ages 10-11).
Vascular assessment included carotid intima-media thickness (ultrasonography) and aortic stiffness (carotid-femoral pulse wave velocity).
Central blood pressure was measured using applanation tonometry.

Main Results:

African American children exhibited significantly higher aortic stiffness (pulse wave velocity) compared to white children, persisting after adjustments.
African American children showed higher intima-media thickness and carotid systolic blood pressure, though these differences diminished after height adjustment.
These findings indicate early racial differences in vascular properties among children.

Conclusions:

Significant racial differences in aortic stiffness are present in childhood.
Subclinical cardiovascular disease markers emerge earlier in childhood than previously recognized.
Early identification of racial disparities in vascular health is essential for pediatric cardiovascular disease prevention.