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Updated: Mar 12, 2026

A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
Structured imaging technique in the gynecologic office for the diagnosis of abnormal uterine bleeding
Margit Dueholm1, Ina Marie D Hjorth1
1Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark.
Insights
This study outlines a structured transvaginal ultrasound approach to diagnose abnormal uterine bleeding (AUB). It simplifies identifying causes using the PALM-COEIN system and guides when further invasive tests are needed.
Area of Science:
- Gynecology
- Diagnostic Imaging
- Reproductive Medicine
Background:
- Abnormal uterine bleeding (AUB) diagnosis requires identifying the cause, often categorized by the PALM-COEIN system.
- Structural abnormalities (PALM causes) are typically the initial focus in gynecologic evaluations for AUB.
- Current diagnostic methods include ultrasonography, endometrial sampling, and hysteroscopy, often used in combination.
Purpose of the Study:
- To describe a structured transvaginal ultrasound (TVS) protocol for simplified AUB diagnosis in routine gynecologic practice.
- To guide the determination of when additional invasive investigations are necessary for AUB.
- To propose diagnostic setups for premenopausal women using the PALM-COEIN system and for postmenopausal women for endometrial cancer screening.
Main Methods:
- Detailed description of a simple, structured transvaginal ultrasound technique.
- Identification of common endometrial and myometrial abnormalities and their ultrasound features.
- Outline of criteria for incorporating Magnetic Resonance Imaging (MRI) when indicated.
Main Results:
- The structured TVS approach aims to simplify the diagnostic process for AUB.
- It facilitates the classification of AUB according to the PALM-COEIN system.
- The protocol helps differentiate between structural and non-structural causes, guiding further management.
Conclusions:
- Structured transvaginal ultrasound is a valuable tool for the initial diagnosis and classification of abnormal uterine bleeding.
- This method can streamline gynecologic practice, reducing the need for immediate invasive procedures.
- Future applications include rapid screening for endometrial cancer in postmenopausal women.
Abstract:
The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy. These options alone or in combination are sufficient for the diagnosis of most women with AUB. Contrast sonography with saline or gel infusion, three-dimensional ultrasonography, and magnetic resonance imaging may be included.
Aim:
The aim of this article is to describe how a simple structured transvaginal ultrasound can be performed and implemented in the common gynecologic practice to simplify the diagnosis of AUB and determine when additional invasive investigations are required. Structured transvaginal ultrasound for the identification of the most common endometrial and myometrial abnormalities and the most common ultrasound features are described. Moreover, situations where magnetic resonance imaging may be included are described. This article proposes a diagnostic setup in premenopausal women for the classification of AUB according to the PALM-COEIN system. Moreover, a future diagnostic setup for fast-track identification of endometrial cancer in postmenopausal women based on a structured evaluation of the endometrium is described.
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