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Brief Report: A Second Primary Endodermal Sinus Tumor 9 Years after Initial Diagnosis.

Lea A Moukarzel1, Kimberly Levinson1, Francis C Grumbine1

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Journal of Pediatric and Adolescent Gynecology
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Summary

Ovarian yolk sac tumors (YSTs) are typically unilateral. This case highlights a rare instance where a YST reappeared in the contralateral ovary 9 years after initial treatment, impacting surveillance strategies.

Keywords:
Alpha-fetoproteinMalignant ovarian germ cell tumorsYolk sac tumors

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Area of Science:

  • Gynecologic Oncology
  • Reproductive Endocrinology
  • Oncology

Background:

  • Ovarian yolk sac tumors (YSTs) are rare malignant germ cell neoplasms.
  • YSTs are generally considered unilateral, facilitating fertility-sparing surgery.
  • Previous bilateral cases were diagnosed at initial presentation with advanced disease.

Observation:

  • A young woman presented with a YST in the contralateral ovary 9 years after initial treatment for a unilateral YST.
  • This represents a unique case of metachronous bilateral ovarian involvement.

Findings:

  • Yolk sac tumors can present bilaterally, even years apart.
  • This challenges the established understanding of YSTs as exclusively unilateral.

Implications:

  • Recurrence patterns and surveillance protocols for ovarian YSTs require re-evaluation.
  • Long-term monitoring is crucial for patients treated for unilateral YSTs.
  • This case underscores the importance of considering contralateral recurrence in YST management.