Redox Status of β₂GPI in Different Stages of Diabetic Angiopathy

We explored the redox status of beta 2 glycoprotein I (β₂GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β₂GPI as compared to healthy controls (p < 0.05). There was a trend that the mild coronal atherosclerosis heart disease (CAD) had higher proportion of reduced β₂GPI than non-CAD and severe-CAD groups, however without significances (p > 0.05). The mild-A-stenosis group and mild-diabetic retinopathy (DR) groups had higher proportion of reduced β₂GPI than their severely affected counterparts. The mild-slow nerve conduction velocity (NCVS) group had higher proportion of reduced β₂GPI than normal nerve conduction velocity (NCVN group) and severe-NCVS groups. The proportion of reduced β₂GPI was in positive correlation with 24 h urine microalbumin and total urine protein, and the proportion of reduced β₂GPI was in negative correlation with serum and skin advanced glycation end products (AGEs). Taken together, our data implicate that the proportion of reduced β₂GPI increased in the early stage of angiopathy and decreased with the aggravation of angiopathy.