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Cytomegalovirus-induced collapsing focal segmental glomerulosclerosis
Vanya Grover1, Meghana R Gaiki2, Maria V DeVita2
1Department of Medicine , North Shore-LIJ Health Care System-Lenox Hill Hospital , New York, NY , USA.
Clinical Kidney Journal
|November 8, 2016
Summary
Collapsing glomerulopathy, a severe kidney disease, can be triggered by cytomegalovirus (CMV) infection even in healthy individuals. Prompt antiviral treatment for CMV may improve kidney function in these rare cases.
Area of Science:
- Nephrology
- Virology
- Immunology
Background:
- Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis.
- It often presents with nephrotic syndrome and rapid kidney failure.
- Human immunodeficiency virus (HIV) is the most common cause.
Purpose of the Study:
- To report a rare case of collapsing glomerulopathy.
- To investigate the association with acute cytomegalovirus (CMV) infection.
- To evaluate the response to antiviral therapy.
Main Methods:
- Case report presentation.
- Clinical and laboratory data review.
- Renal function assessment before and after treatment.
Main Results:
- A rare case of collapsing glomerulopathy in an immunocompetent host was identified.
- The patient had acute cytomegalovirus (CMV) infection.
- Renal function improved after ganciclovir treatment for CMV.
Conclusions:
- Cytomegalovirus (CMV) may be an under-recognized cause of collapsing glomerulopathy.
- Antiviral treatment for CMV can lead to recovery of renal function.
- This highlights the importance of considering viral etiologies in collapsing glomerulopathy.
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