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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
An unusual case of Salmonella Enteritidis causing pneumonia, septic shock and multiple organ failure in an
M L Thompson Bastin1, N R Neville2, R E Parsons2
1University of Kentucky HealthCare, Department of Pharmacy Services, 800 Rose Street H110, Lexington, KY 40536, USA; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, 800 Rose Street H110 Lexington, KY 40536, USA.
Abstract:
Salmonella species are facultative intracellular pathogens that most frequently cause self-limiting gastrointestinal disease, often acquired through the ingestion of contaminated food. We report the case of a 33-year-old otherwise healthy, not overtly immunosuppressed, man who was transferred to our facility with the chief complaint of respiratory failure and septic shock. Computed tomography of the chest revealed multifocal pneumonia in both lungs. A bronchial alveolar lavage was performed in the right middle lobe and cultures predominantly grew Salmonella enterica serovar Enteritidis. The patient received a prolonged course of antimicrobials, ultimately changing to oral levofloxacin. The etiology of the salmonella infection likely occurred through an aspiration event. Salmonella species are not a typical respiratory pathogen in immunocompetent hosts; however, clinicians should be aware of the possibility that salmonella species may be a pathogenic source of infection in the lungs; a prolonged course of antimicrobials may be warranted.
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