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Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
Published on: August 27, 2021
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Evolution of phage display technology: from discovery to application.
Leila Rahbarnia1,2, Safar Farajnia1, Hossein Babaei1
1a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Journal of Drug Targeting
|November 8, 2016
Summary
Phage display technology enables the evolution of novel biological drugs by presenting proteins on bacteriophage surfaces. This review covers its molecular basis and applications in developing therapeutic antibodies, peptides, vaccines, and catalytic antibodies.
Area of Science:
- Biotechnology
- Molecular Biology
- Drug Discovery
Background:
- Phage display is a powerful selection-based system for evolving new biological drugs.
- It utilizes bacteriophage surfaces to display proteins, contributing to disease diagnosis and therapy research.
Purpose of the Study:
- To review the molecular basis of phage display libraries.
- To summarize novel applications of phage display in biological drug development.
Main Methods:
- Review of existing literature on phage display technology.
- Analysis of applications in therapeutic antibody, peptide, vaccine, and catalytic antibody development.
Main Results:
- Phage display offers a versatile platform for protein evolution.
- Specific applications include the development of therapeutic proteins and vaccines.
Conclusions:
- Phage display technology is crucial for advancing biological drug development.
- Continued modification and application of this technique hold significant promise for future therapeutics.
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