[H3-dopamine release in experimental mild cranio-cerebral trauma]

The studies of ELCCT influence on spontaneous and KCl-stimulated 3H-dopamine release by synaptosomes isolated from the rabbit brain hemispheres and diencephalic-brainstem areas are presented in this paper. Kinetic characteristics of the releasing system (Bm and Vo) were shown to decrease at earlier stages (15 minutes to 2 hrs) and increase at later stages (1 to 14 days). No substantial difference was shown in release responses of the synaptosomes derived from brain hemispheres and diencephalic-brainstem regions. The data suggest the major alterations in the mechanisms of dopamine release in ELCCT.