[Genetico-mathematical analysis of manifested schizophrenia with a permanent and attack-like course]

The parameters of multifactorial and monolocal models were evaluated according to the incidence indices of the manifested forms of schizophrenia in three population groups of Tomsk regions among the relatives of probands with permanent and attack-like course of the disease. Higher occurrence of mutant homozygotes and increase of the share of these genotypes were detected in permanent course of the manifested schizophrenia. The authors suggest that the differences in genetical parameters of susceptibility to the disease with permanent and attack-like course are caused by influence of constitutional factors on the mutant genes penetrant ability.