[Tolerance of antiepileptic therapy]

In 207 epileptic patients with unfavorable course of the disease the results of tolerance to antiepileptic therapy were investigated. The intolerance appeared at different stages of treatment as allergy (15%), intoxication (45%), hypovitaminosis (40%). The tolerance to combined therapy dosages was changing because of: the severity of organic CNS damage which manifested the epilepsy (head trauma, neuroinfection), residual signs of the pathology, progredience of the epileptic process and the therapy tactical drawbacks. The principles controlling the anticonvulsant therapy tolerance were formulated with due account of therapeutic tactics in progredient and slow-progredient epilepsy at its different stages.