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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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RETRACTED ARTICLE: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple

Mehrdad Farrokhi1, Pedram Moeini1, Mohammad Fazilati2

  • 1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Immunological Investigations
|November 8, 2016
PubMed

Insights

This article investigating CD14 gene polymorphisms and multiple sclerosis risk is retracted due to concerns about author affiliations, ethical approval, and data integrity. The study

Area of Science:

  • Immunology
  • Genetics
  • Neurology

Background:

  • The article explored the association between CD14 gene polymorphisms and multiple sclerosis (MS).
  • Soluble CD14 levels were investigated as a potential intermediate marker.

Purpose of the Study:

  • To determine if CD14 gene variations influence soluble CD14 levels.
  • To assess the role of these variations as risk factors for multiple sclerosis.

Main Methods:

  • Genotyping for CD14 gene polymorphisms.
  • Measurement of soluble CD14 levels.
  • Statistical analysis to correlate genotypes, levels, and MS status.

Main Results:

  • The study suggested potential links between CD14 polymorphisms, soluble CD14 levels, and MS risk.
  • Flow cytometry data was initially provided but did not fully resolve concerns.

Conclusions:

  • The findings indicated that CD14 gene polymorphisms might modify soluble CD14 levels and act as risk factors for MS.
  • However, the article has been retracted due to unresolved issues with data integrity and ethical approval.

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