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Lavage fluid from continuous ambulatory peritoneal dialysis. A model for mesothelial cell changes
W Hoeltermann1, E Schlotmann-Hoeller, M Winkelmann
1Department of Pathology, University of Düsseldorf, Federal Republic of Germany.
Acta Cytologica
|September 1, 1989
Summary
Continuous ambulatory peritoneal dialysis (CAPD) lavage reveals frequent inflammatory reactions and mesothelial changes. These cytologic findings in CAPD fluid did not correlate with blood chemistry markers like BUN and creatinine over time.
Area of Science:
- Nephrology
- Cytopathology
- Peritoneal Dialysis
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) involves lavage fluid that can mimic ascites.
- Understanding the cellularity of CAPD lavage is crucial for patient monitoring.
Purpose of the Study:
- To investigate the cellular content of CAPD lavage fluid.
- To identify common cytologic changes and their frequency in CAPD patients.
Main Methods:
- Analysis of 362 CAPD lavage specimens from 32 patients.
- Cytologic examination for inflammatory reactions, eosinophilia, mesothelial aggregates, and atypical mitoses.
Main Results:
- 85.3% of specimens showed irregular inflammatory reactions.
- Eosinophilia was observed in 27.6% of samples.
- Mesothelial aggregates were present in 59.4%, with atypical mitoses in 7.5%.
Conclusions:
- CAPD lavage frequently exhibits inflammatory and mesothelial cellular changes.
- These cytologic findings did not correlate with blood urea nitrogen (BUN) and creatinine levels over 10-12 months.