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Healthcare Associated Infections II: Preventive Measures01:22

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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CA-MRSA Decolonization Strategies: Do They Reduce Recurrence Rate?

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  • 1Joling Tidwell, RN, CPN, Riley Hospital for Children @ IUHealth, Indianapolis, Indiana. Lisa Kirk, MSN, RN, CWOCN, Riley Hospital for Children @ IUHealth, Indianapolis, Indiana. Tim Luttrell, RN, CWOCN, Riley Hospital for Children @ IUHealth, Indianapolis, Indiana. Caitlin A. Pike, MLS, AHIP, IUPUI University Library, Indianapolis, Indiana.

Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society
|November 8, 2016
PubMed
Summary

Decolonization strategies may reduce methicillin-resistant Staphylococcus aureus (MRSA) colonization but do not consistently decrease skin and soft tissue infection (SSTI) recurrence. Further research is needed to establish effective decolonization protocols for preventing MRSA-SSTI.

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Public Health

Background:

  • Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) frequently causes skin and soft tissue infections (SSTIs).
  • Recurrence of MRSA-SSTIs is common, even after standard treatment like incision and drainage.

Purpose of the Study:

  • To review evidence on decolonization strategies for reducing MRSA-SSTI recurrence or colonization.
  • To evaluate the effectiveness of decolonization in patients with a history of MRSA-SSTI.

Main Methods:

  • Systematic literature review from 1987 to present.
  • Included studies focused on decolonization to decrease MRSA-SSTI recurrence.
  • Analyzed 12 studies meeting inclusion criteria from an initial search of 754 articles.

Main Results:

  • Topical decolonization reduced MRSA colonization rates in four studies.
  • Combination decolonization therapy decreased colonization in 3 of 4 studies.
  • Despite successful decolonization, MRSA-SSTI recurrence rates did not consistently decrease.

Conclusions:

  • Insufficient evidence supports routine decolonization for preventing recurrent MRSA-SSTIs.
  • Focus should be on preventing infection spread through hygiene education for patients and contacts.