Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.5K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

11.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
11.1K
The Retina01:32

The Retina

78.2K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
78.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bupivacaine-Induced Regeneration in Rabbit Extraocular Muscles: Implications for the Treatment of Strabismus.

Ophthalmology science·2026
Same author

Applications of Generative Artificial Intelligence for Strabismus Surgery Video-Based Education.

Ophthalmology science·2026
Same author

Evaluating the clinical utility of multimodal large language models in rare maculopathy.

Scientific reports·2025
Same author

But doctor, will I be able to drive? Car mirror placement design and viewing angles required for safe binocular vision for drivers.

The British journal of ophthalmology·2025
Same author

Epidemiology of strabismus among adults in the United States: insights from the All of Us database.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2025
Same author

Socioeconomic trends of adult strabismus in the United States: an analysis of the All of Us database.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2025
Same journal

Acute Paracentral Scotoma Following Cosmetic Penile Filler Injection.

Retinal cases & brief reports·2026
Same journal

Intravitreous Methotrexate and Rituximab for Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP).

Retinal cases & brief reports·2026
Same journal

Multimodal imaging of ASHH in a case of Scrub Typhus Retinopathy.

Retinal cases & brief reports·2026
Same journal

Pathogenic Variants in HGSNAT associated with Autosomal Recessive Retinitis Pigmentosa without Overt Sanfilippo Syndrome.

Retinal cases & brief reports·2026
Same journal

Macular Choroidal Neovascularization in Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS): case report.

Retinal cases & brief reports·2026
Same journal

Endogenous Streptococcus Anginosus Endophthalmitis: A Case Report and Review of the Literature.

Retinal cases & brief reports·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards
08:38

Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards

Published on: September 3, 2020

6.7K

ELECTRONEGATIVE ELECTRORETINOGRAM IN ACHROMATOPSIA.

Craig S Schallhorn1, David B Granet2, Henry A Ferreyra2

  • 1Naval Medical Center San Diego, San Diego, California.

Retinal Cases & Brief Reports
|November 8, 2016
PubMed
Summary
This summary is machine-generated.

Novel electroretinography findings in achromatopsia reveal an electronegative configuration, potentially indicating inner retinal dysfunction. This case highlights unique electroretinographic patterns in achromatopsia patients.

More Related Videos

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

5.9K
Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats
10:30

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

13.0K

Related Experiment Videos

Last Updated: Mar 12, 2026

Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards
08:38

Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards

Published on: September 3, 2020

6.7K
Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

5.9K
Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats
10:30

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

13.0K

Area of Science:

  • Ophthalmology
  • Genetics
  • Neuroscience

Background:

  • Achromatopsia is a rare inherited retinal disorder characterized by reduced visual acuity, photophobia, and complete absence of color vision.
  • Genetic mutations in CNGA3 and CNGB3 genes are the primary cause of achromatopsia.
  • Electroretinography (ERG) is a crucial diagnostic tool for evaluating retinal function in inherited retinal diseases.

Observation:

  • A patient with achromatopsia presented with childhood nystagmus, photoaversion, and absent color vision.
  • Ophthalmoscopic examination showed no distinct abnormalities.
  • Electroretinography under anesthesia revealed absent photopic responses and an electronegative configuration in dark-adapted combined responses.

Findings:

  • Genetic testing identified two heterozygous sequence variations (Arg223Trp and Pro372Ser) in the CNGA3 gene, confirming achromatopsia.
  • These variations were previously described in achromatopsia cases and confirmed to be on separate alleles in the patient's parents.
  • The observed electronegative ERG configuration in this achromatopsia case is a novel finding.

Implications:

  • The novel electroretinography findings, particularly the electronegative configuration, suggest a potential component of inner retinal dysfunction in achromatopsia.
  • This case expands the understanding of electroretinographic variability in achromatopsia.
  • Further research is warranted to elucidate the precise mechanisms underlying the observed ERG patterns and their clinical significance.