Related Experiment Video

Updated: Mar 12, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Update on Lupus Nephritis

Salem Almaani1, Alexa Meara, Brad H Rovin

  • 1Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio.

Clinical Journal of the American Society of Nephrology : CJASN
|November 9, 2016
PubMed

Insights

Systemic lupus erythematosus (SLE) can cause lupus nephritis, a kidney disease. This review focuses on recent advances in understanding and managing lupus nephritis to preserve long-term kidney function.

Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs.
  • Kidney involvement, known as lupus nephritis, occurs in approximately 50% of SLE patients.
  • Lupus nephritis significantly increases morbidity and mortality, often leading to chronic kidney disease (CKD) or end-stage renal disease (ESRD).

Purpose of the Study:

  • To review recent advancements in the epidemiology, genetics, and pathogenesis of lupus nephritis.
  • To outline a framework for patient-specific management strategies for lupus nephritis.
  • To emphasize the goal of preserving long-term kidney function in patients with SLE.

Main Methods:

  • Comprehensive literature review of recent studies on lupus nephritis.
  • Analysis of current understanding of disease mechanisms and genetic factors.
  • Synthesis of updated therapeutic approaches and management guidelines.

Main Results:

  • Recent research has expanded the understanding of SLE and lupus nephritis epidemiology and genetics.
  • New insights into pathogenesis provide targets for novel therapies.
  • Current treatments, while potent, still result in significant rates of CKD/ESRD, highlighting the need for improved management.

Conclusions:

  • Effective management of lupus nephritis requires a patient-specific approach.
  • Focusing on early diagnosis, understanding individual risk factors, and tailored treatment is crucial.
  • Continued research and updated management frameworks are essential to improve long-term kidney outcomes for SLE patients.

Keywords:
ChronicDiscoidEpidemiology and outcomesLupus ErythematosusRenal InsufficiencySystemicchronicglomerular diseaseglomerulonephritishumansimmunosuppressionkidneykidney failurelupus nephritisnephritisrisk factorssystemic lupus erythematosus

More Related Videos

Murine Bilateral Renal Lymphadenectomy06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

128
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

19.0K

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.2K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
807
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.1K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
293
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
973
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
411