Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.8K
Oogenesis02:07

Oogenesis

70.9K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
70.9K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.7K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.7K
Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
Stem Cell Niche01:26

Stem Cell Niche

6.5K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential expression of microRNAs after induction of endometriosis in baboons.

Biology of reproduction·2026
Same author

Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program.

Human reproduction (Oxford, England)·2026
Same author

Progestin therapy in premenopausal women with incidental meningioma-a narrative review and recommendations for women's health specialists.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same author

Corrigendum to 'Endometriosis and ovarian cancer risk' [Gynecologic Oncology 209C (2026) 88-98].

Gynecologic oncology·2026
Same author

slideimp: efficient imputation of DNA methylation data.

Bioinformatics (Oxford, England)·2026
Same author

Circulating transfer RNA-derived fragment abundance after experimental endometriosis induction in baboons.

Molecular human reproduction·2026

Related Experiment Video

Updated: Mar 12, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.9K

Endometriosis and Stem Cell Trafficking.

Nicola Pluchino1, Hugh S Taylor2

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.

Reproductive Sciences (Thousand Oaks, Calif.)
|November 9, 2016
PubMed
Summary
This summary is machine-generated.

Adult stem cells are crucial for uterine repair but also drive endometriosis. Endometriosis depletes circulating stem cells, impairing uterine function and highlighting stem cell trafficking as a key therapeutic target.

Keywords:
cell traffickingendometriosisendometriumstem cells

More Related Videos

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

1.3K
Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

10.0K

Related Experiment Videos

Last Updated: Mar 12, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.9K
Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

1.3K
Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

10.0K

Area of Science:

  • Reproductive biology
  • Stem cell research
  • Gynecology

Background:

  • Adult stem cells are vital for endometrial repair and regeneration.
  • These stem cells play a dual role, contributing to both normal uterine function and the development/progression of endometriosis.

Purpose of the Study:

  • To investigate the role of adult stem cells, specifically bone marrow-derived stem cells (BMDSCs), in the context of endometriosis.
  • To understand the mechanisms of stem cell trafficking in endometriosis and its impact on endometrial function.

Main Methods:

  • The study examines the engraftment and fate of BMDSCs in eutopic endometrium and endometriotic lesions.
  • It analyzes the impact of endometriosis on circulating stem cell populations and their homing capabilities.
  • Investigates stem cell migration from endometriotic lesions to the uterus.

Main Results:

  • BMDSCs can engraft in both normal uterine lining and endometriotic tissues, differentiating into stromal and epithelial cells.
  • Endometriosis leads to a decrease in circulating BMDSCs, hindering their ability to reach the uterus.
  • Stem cells migrate from endometriotic lesions into the uterus, causing endometrial dysfunction.

Conclusions:

  • Stem cell trafficking is a fundamental aspect of endometriosis pathogenesis.
  • Understanding the molecular regulation of stem cell mobility and engraftment in endometriosis is crucial for developing novel therapeutic strategies.