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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Joanna Jaroch1, Olga Vriz2, Zbigniew Bociąga1

  • 1Department of Cardiology, T Marciniak Hospital, Wroclaw, Poland.

Clinical Interventions in Aging
|November 9, 2016
PubMed

Insights

Arterial stiffness predicts left ventricular diastolic dysfunction differently in men and women with hypertension. Diabetes is key for women, while systolic function and arterial stiffness are key for men.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Biology

Background:

  • Sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors are not well understood.
  • Arterial stiffness (AS) may have a differential role in LV DD etiology between hypertensive men and postmenopausal women.
  • Established predictors include age, obesity, diabetes mellitus, LV remodeling, and systolic function.

Purpose of the Study:

  • To investigate sex-specific differences in AS and other LV DD predictors.
  • Focus on men and postmenopausal women with untreated hypertension (HTN).

Main Methods:

  • Study included 144 patients (63 postmenopausal women, 81 men) with untreated HTN.
  • Methods included echocardiography, vascular ultrasound, and carotid artery echotracking.
  • No prior history of cardiovascular diseases in participants.

Main Results:

  • Diabetes mellitus independently predicted LV DD in women (P=0.02).
  • In men, S' (LV systolic longitudinal function) (P=0.001) and beta stiffness index (AS parameter) (P=0.004) independently predicted LV DD.
  • Multivariate analysis identified these distinct predictors.

Conclusions:

  • Significant sex differences exist in LV DD predictors for untreated hypertension.
  • In postmenopausal women, diabetes is the primary determinant of LV DD.
  • In men, LV DD is determined by systolic function (S') and arterial stiffness (β).
Abstract

Keywords:
hypertensionleft ventricular diastolic dysfunctionsex differences

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