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The Danish Fetal Medicine database.

Charlotte Kvist Ekelund¹, Tine Iskov Kopp², Ann Tabor¹

¹Department of Obstetrics, Center of Fetal Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Clinical Epidemiology

|November 9, 2016

Summary

A new Danish fetal medicine database successfully monitors screening for chromosomal abnormalities and fetal malformations. This system allows for regional performance assessment and national comparison with international data.

Keywords:

chromosomal abnormalities fetal malformations nuchal translucency prenatal screening

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Area of Science:

Perinatology
Medical Informatics
Public Health

Background:

First-trimester screening for chromosomal abnormalities and second-trimester screening for fetal malformations are crucial components of prenatal care.
Accurate monitoring of detection and false-positive rates is essential for evaluating and improving screening programs.
Denmark aimed to establish a centralized system for comprehensive data collection and analysis.

Approach:

A central fetal medicine database was established, integrating data from all public hospitals in Denmark.
Maternal characteristics, ultrasound, and biochemical data were collected via web service from existing Astraia databases.
Pregnancy outcomes and chromosome analysis results were linked using the unique personal registration number from national registers.

Key Points:

The database successfully integrates data from multiple sources, including hospital records and national registries.
It enables continuous monitoring of detection rates and false-positive rates for first-trimester screening.
Prenatal detection rates for major fetal malformations in the second trimester are also tracked.

Conclusions:

A functional fetal medicine database has been established in Denmark.
The database effectively monitors first-trimester screening for chromosomal abnormalities and second-trimester screening for fetal malformations.
This system provides a valuable tool for assessing regional performance and comparing national results internationally.