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Clinical Subgroups in Bilateral Meniere Disease.
Lidia Frejo1, Andres Soto-Varela2, Sofía Santos-Perez2
1Otology and Neurotology Group CTS495, Department of Genomic Medicine - Centro de Genómica e Investigación Oncológica - Pfizer/Universidad de Granada/Junta de Andalucía (GENYO) , Granada , Spain.
Frontiers in Neurology
|November 9, 2016
Summary
Meniere disease (MD) patients with bilateral involvement were classified into five distinct clinical variants. This phenotyping aids in understanding diverse etiologies and developing targeted treatments for this heterogeneous condition.
Area of Science:
- Otolaryngology
- Neurology
- Genetics
Background:
- Meniere disease (MD) is a complex condition with sensorineural hearing loss, vestibular issues, and tinnitus.
- Bilateral MD (BMD) affects 5-50% of patients, with involvement frequency influenced by disease duration.
- Comorbidities like migraine and autoimmune disorders (AD) are common in MD.
Purpose of the Study:
- To identify clinical subgroups within bilateral Meniere disease (BMD) using cluster analysis.
- To define predictors for distinct clinical variants of BMD.
- To improve phenotyping for better understanding of BMD etiology and treatment development.
Main Methods:
- Two-step cluster analysis was applied to a cohort of 398 patients with bilateral MD.
- Patients were analyzed for hearing loss patterns (metachronic/synchronic), familial history, migraine, and autoimmune disorders.
- Clinical variants were identified based on distinct predictor combinations.
Main Results:
- Five distinct clinical variants of BMD were identified.
- Variant 1 (46%): Metachronic hearing loss, no migraine, no AD.
- Variant 2 (17%): Synchronic hearing loss, no migraine, no AD.
- Variant 3 (13%): Familial MD.
- Variant 4 (12%): Associated with migraine.
- Variant 5 (11%): Associated with AD.
Conclusions:
- The identified clinical variants offer a refined phenotyping of bilateral Meniere disease.
- This classification can facilitate patient selection for genetic and clinical research.
- Further investigation is needed to elucidate the diverse etiological factors underlying these BMD variants.
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