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Updated: Mar 12, 2026

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
Oncogene-directed alterations in cancer cell metabolism
Arvindhan Nagarajan1, Parmanand Malvi1, Narendra Wajapeyee2
1Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510.
Abstract:
Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns in cancer cells is only beginning to be appreciated. Recent studies show that oncogenes directly regulate critical metabolic enzymes and metabolic signaling pathways. Here, we present evidence for oncogene-directed cancer metabolic regulation and discuss the importance of identifying underlying mechanisms that can be targeted for developing precision cancer therapies.
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