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ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic

Kei Morio1, Michio Imamura1, Yoshiiku Kawakami1

  • 1Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Journal of Gastroenterology
|November 9, 2016
PubMed
Summary

Inosine triphosphatase (ITPA) gene variants affect anemia risk and ribavirin (RBV) dosing during sofosbuvir treatment for hepatitis C. ITPA genotype CC patients experienced more anemia but achieved similar sustained virological response rates.

Keywords:
Chronic hepatitis CHemoglobinITPARibavirinSofosbuvir

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