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Are Cystic Fibrosis Aspergillus fumigatus Isolates Different? Intermicrobial Interactions with Pseudomonas

Hasan Nazik1,2,3, Richard B Moss4, Vyshnavi Karna1

  • 1California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.

Mycopathologia
|November 9, 2016
PubMed

Insights

Pseudomonas aeruginosa biofilms are susceptible to Aspergillus fumigatus in cystic fibrosis (CF). However, CF-adapted Aspergillus isolates showed no difference in susceptibility to Pseudomonas aeruginosa compared to non-CF strains.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Cystic Fibrosis Research

Background:

  • Pseudomonas aeruginosa and Aspergillus fumigatus are primary pathogens in cystic fibrosis (CF) airways.
  • CF-resident Pseudomonas aeruginosa exhibits significant genetic and phenotypic adaptations.
  • Previous studies indicated altered antifungal susceptibility in Aspergillus fumigatus from CF patients.

Purpose of the Study:

  • To investigate if Aspergillus fumigatus isolates from CF patients exhibit altered susceptibility to Pseudomonas aeruginosa.
  • To compare the susceptibility of CF-adapted Aspergillus to Pseudomonas aeruginosa with non-CF Aspergillus strains.

Main Methods:

  • Comparative analysis of Pseudomonas aeruginosa susceptibility.
  • Utilized reference virulent non-CF Aspergillus and Aspergillus isolates from CF patients.
  • Evaluated biofilm susceptibility.

Main Results:

  • Pseudomonas aeruginosa biofilms demonstrated susceptibility to Aspergillus fumigatus, particularly CF phenotypes.
  • CF-derived Aspergillus isolates did not show altered susceptibility to Pseudomonas aeruginosa compared to non-CF isolates.
  • The CF environment does not appear to alter Aspergillus' susceptibility to Pseudomonas.

Conclusions:

  • While Pseudomonas aeruginosa biofilms are susceptible to Aspergillus, the CF environment does not significantly alter Aspergillus' susceptibility to Pseudomonas.
  • CF-associated Aspergillus isolates maintain similar susceptibility profiles to Pseudomonas aeruginosa as non-CF isolates.
  • Further research may explore other interactions between CF pathogens.
Keywords:
AspergillusBiofilmCystic fibrosisIntermicrobial interactionPseudomonas

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