Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

161
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
161
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling antioxidant and anti-inflammatory potentials of <i>Garcinia microphylla</i> Merr.: first report on metabolomics studies, <i>in vitro</i> and <i>in vivo</i> approaches.

Natural product research·2026
Same author

REST deficiency and neurogenic-to-gliogenic shift in down syndrome human cerebral organoids.

Molecular brain·2026
Same author

Naringenin-Loaded Zinc Nitrate and Manganese Nitrate Nanoparticles Induce Caspase-Dependent Apoptosis in Kidney Cancer A-498 Cells.

Dose-response : a publication of International Hormesis Society·2026
Same author

Antibacterial performance of chitosan-modified magnesium fluoride nanoparticles: Synthesis and characterization.

International journal of biological macromolecules·2026
Same author

Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties.

International journal of biological macromolecules·2026
Same author

Protective effects of the natural polyphenol garcinol from Garcinia indica mitigates aluminium chloride-induced Alzheimer's-like neurodegeneration in <i>Drosophila melanogaster</i>.

3 Biotech·2026

Related Experiment Video

Updated: Mar 12, 2026

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.2K

Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy.

Dena Dorniani1,2, Bullo Saifullah2, Farahnaz Barahuie2,3

  • 1Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, UK.

Nanoscale Research Letters
|November 9, 2016
PubMed
Summary

This study developed a graphene oxide (GO) and gallic acid (GA) nanocomposite (GOGA) for targeted cancer therapy. The GOGA system effectively inhibited liver cancer cell growth while sparing normal cells.

Keywords:
Controlled-releaseCytotoxicityDrug delivery systemsGallic acidGraphene oxide

More Related Videos

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.6K
Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

28.8K

Related Experiment Videos

Last Updated: Mar 12, 2026

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.2K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.6K
Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

28.8K

Area of Science:

  • Biomedical Science
  • Nanotechnology
  • Materials Science

Background:

  • Cancer remains a significant global health challenge despite advances in biomedical science.
  • Developing effective and targeted drug delivery systems is crucial for improving cancer treatment outcomes.
  • Graphene oxide (GO) offers potential as a nanocarrier due to its unique properties.

Purpose of the Study:

  • To design and characterize a novel anticancer nanodelivery system using graphene oxide (GO) as a carrier for gallic acid (GA).
  • To evaluate the in vitro efficacy of the developed gallic acid-graphene oxide nanocomposite (GOGA) against liver cancer cells.

Main Methods:

  • Synthesis and characterization of the gallic acid-graphene oxide nanocomposite (GOGA) using techniques like XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy.
  • In vitro release studies of gallic acid from the GOGA nanocomposite in phosphate-buffered saline (PBS) at pH 7.4.
  • In vitro cytotoxicity assays using normal fibroblast (3T3) and liver cancer cells (HepG2) treated with GO, GOGA, and GA.

Main Results:

  • The GOGA nanocomposite was successfully synthesized and characterized.
  • Sustained release of gallic acid from the GOGA nanocomposite was observed at physiological pH (7.4).
  • The GOGA nanocomposite demonstrated significant inhibition of liver cancer cell (HepG2) growth without adversely affecting normal fibroblast cells (3T3).

Conclusions:

  • The developed GOGA nanocomposite is a promising targeted anticancer nanodelivery system.
  • This system exhibits selective toxicity towards cancer cells, highlighting its therapeutic potential.
  • Further in vivo studies are warranted to explore the full therapeutic capabilities of the GOGA nanocomposite.