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Measuring nasal nitric oxide in allergic rhinitis patients
V S Nesic1, V Z Djordjevic1, V Tomic-Spiric1
1School of Medicine,University of Belgrade,Belgrade,Serbia.
The Journal of Laryngology and Otology
|November 9, 2016
Summary
Allergic rhinitis patients show higher nasal nitric oxide levels than healthy individuals. Nasal nitric oxide measurement is a reliable tool for diagnosing allergic rhinitis in out-patient settings.
Area of Science:
- Respiratory Medicine
- Allergology
- Clinical Diagnostics
Background:
- Nitric oxide (NO) plays a role in airway inflammation.
- Elevated NO levels are associated with allergic conditions.
- Standardized measurement of nasal NO is crucial for clinical application.
Purpose of the Study:
- To compare two distinct nasal nitric oxide (NO) sampling methods.
- To assess the reliability of nasal NO measurements within subjects.
- To evaluate NO levels in allergic rhinitis patients versus healthy controls.
Main Methods:
- Included 23 allergic rhinitis patients and 10 healthy controls.
- Measured oral fractional exhaled NO and nasal NO.
- Nasal NO assessed via nasal aspiration and facemask exhalation against resistance.
Main Results:
- Allergic rhinitis patients exhibited significantly higher oral and nasal NO levels compared to healthy individuals.
- Both nasal NO measurement methods demonstrated excellent within-subject reliability.
- Oral NO levels were also elevated in allergic rhinitis patients.
Conclusions:
- Nasal nitric oxide measurement is a dependable clinical method for diagnosing allergic rhinitis in non-asthmatic patients.
- This technique is suitable for use in out-patient clinical settings.
- Reliable NO measurements support its utility in allergic rhinitis diagnosis.
