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Updated: Mar 12, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

Giuseppe Bronte1, Lorena Incorvaia1, Sergio Rizzo1

  • 1Section of Medical Oncology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Critical Reviews in Oncology/Hematology
|November 9, 2016
PubMed

Insights

Malignant pleural mesothelioma (MPM) lacks standard second-line treatments. Targeted therapies show promise, but patient selection based on genetic markers is crucial for effective treatment strategies.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Molecular Biology

Background:

  • Malignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis.
  • Current first-line treatments include platinum compounds and pemetrexed, but no standard second-line options exist.
  • Understanding MPM's molecular biology is key to developing new therapies.

Purpose of the Study:

  • To review biological pathways in MPM.
  • To analyze clinical trials of targeted therapies for MPM.
  • To explore resistance mechanisms and identify potential therapeutic targets.

Main Methods:

  • Literature review of MPM biological pathways.
  • Analysis of clinical trial data for targeted MPM treatments.
  • Investigation of resistance mechanisms to targeted therapies.

Main Results:

  • Several targeted treatments have been investigated in clinical trials for MPM.
  • No targeted treatments are currently recommended for routine use in MPM.
  • Specific genetic markers are needed for patient selection in targeted therapy.

Conclusions:

  • Targeted therapy holds potential for MPM, but requires further refinement.
  • Identifying predictive biomarkers is essential for personalized MPM treatment strategies.
  • Molecular profiling can guide the selection of the most effective drug for individual MPM patients.
Keywords:
MesotheliomaPleuraResistanceTargeted therapy

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