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Hypertension in adults with repaired coarctation of the aorta

Daniel Rinnström1, Mikael Dellborg2, Ulf Thilén3

  • 1Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

American Heart Journal
|November 9, 2016
PubMed

Insights

Hypertension is common in adults with repaired coarctation of the aorta (CoA). Risk factors include older age, male sex, higher BMI, and arm-leg blood pressure differences.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Public Health

Background:

  • Coarctation of the aorta (CoA) is a congenital heart defect.
  • Adults with repaired CoA often develop long-term complications.
  • Hypertension (HTN) is a significant concern in this population.

Purpose of the Study:

  • To determine the prevalence of hypertension in adults with repaired CoA.
  • To identify factors associated with hypertension in this cohort.

Main Methods:

  • Analysis of data from a national register for congenital heart disease.
  • Inclusion of 653 adults with repaired CoA (mean age 36.9 years).
  • Multivariable modeling to assess associations with hypertension.

Main Results:

  • 52.7% of patients had hypertension (diagnosed or BP ≥140/90mmHg).
  • Independent risk factors for HTN included increasing age, male sex, and higher body mass index.
  • Systolic arm-leg blood pressure gradient was significantly associated with HTN.

Conclusions:

  • Hypertension is highly prevalent in adults with a history of repaired CoA.
  • Age, male sex, BMI, and arm-leg blood pressure gradient are key associated factors.
  • Even mild arm-leg blood pressure gradients may indicate increased HTN risk.
Abstract

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