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Updated: Mar 12, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
"Hepatocellular carcinoma: A life-threatening disease"
1Division of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.
Insights
Liver cancer, specifically Hepatocellular Carcinoma (HCC), is a growing global health concern, particularly in males. Current treatments offer limited success, highlighting the urgent need for novel drug development and personalized medicine approaches.
Area of Science:
- Oncology
- Hepatology
- Cancer Research
Background:
- Hepatocellular Carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer death globally.
- HCC incidence is projected to rise, with males affected three to four times more frequently than females.
- Hepatitis C Virus (HCV)-related liver cancer is rapidly increasing in the US due to limited treatment options.
Purpose of the Study:
- To highlight the increasing incidence and mortality of Hepatocellular Carcinoma (HCC).
- To underscore the limitations of current HCC treatment strategies.
- To emphasize the critical need for developing new drugs and personalized medicine for HCC.
Main Methods:
- Review of epidemiological data on liver cancer incidence and mortality.
- Analysis of current therapeutic interventions for HCC.
- Identification of gaps in HCC treatment and patient prognosis.
Main Results:
- Liver cancer incidence is projected to reach 95,374 new cases by 2020.
- HCC is the third leading cause of cancer-related deaths worldwide.
- Despite available treatments like transplantation, resection, and chemotherapy, patient prognosis remains poor.
Conclusions:
- Liver transplantation offers high survival rates but is limited by donor scarcity.
- There is an urgent need for the development of targeted therapies and personalized medicine for Hepatocellular Carcinoma.
- Addressing the rising incidence of HCC requires innovative treatment strategies beyond current options.
Abstract:
An estimated rise in liver cancer incidence will increase to 95374 new cases by 2020. Hepatocellular Carcinoma (HCC), the most common primary malignant tumour of the liver, is considered to be the third leading cause of all cancer-related deaths and fifth common cancer worldwide. The reported data shows that the rate of HCC incidence in male population is three to four times higher compared with the female population. In the United States, HCV-induced liver cancer is increasing very fast because of the lack of proper treatment option. There are various treatment strategies available for HCC like liver transplantation, resection, ablation, embolization and chemotherapy still the prognosis is destitute. If the patient is eligible, liver transplantation is the only therapeutic option that may give around 90% survival rate, but the scarcity of liver donor limits its broad applicability. A sudden address is necessary to develop specific drugs, personalized medicine, for HCC.
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