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Growth trajectories and asthma/rhinitis in children: a longitudinal study in Taiwan

Yang-Ching Chen1,2,3, Tsan-Hon Liou4, Pau-Chung Chen5,6

  • 1Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan.

The European Respiratory Journal
|November 9, 2016
PubMed

Insights

Persistently overweight children face higher risks of developing asthma and rhinitis throughout adolescence and early adulthood. This study highlights the long-term impact of childhood weight trajectories on respiratory health.

Area of Science:

  • Pediatric Allergy and Immunology
  • Growth and Development Studies
  • Epidemiology

Background:

  • Childhood body weight is linked to asthma, but school-age growth patterns' impact on asthma and rhinitis is unclear.
  • Understanding growth trajectories is crucial for predicting allergic respiratory diseases.

Purpose of the Study:

  • To investigate if distinct childhood growth patterns predict incident asthma and rhinitis.
  • To analyze the long-term effects of weight trajectories on respiratory health outcomes.

Main Methods:

  • Nationwide longitudinal study (Taiwan Children Health Study) of 4422 children aged 6-11 years.
  • Latent mixture modeling identified growth trajectory classes based on Body Mass Index (BMI) z-scores.
  • Discrete time hazard models assessed prediction of asthma and rhinitis at ages 12, 15, and 18 years, with pulmonary function and FeNO measurements.

Main Results:

  • Four distinct growth trajectory classes were identified.
  • Persistently overweight children showed significantly increased risks of asthma and rhinitis at age 12.
  • Persistent overweight status predicted incident asthma (HR 2.47) and rhinitis (HR 1.44) in adolescence/early adulthood.

Conclusions:

  • Persistently overweight children exhibit a higher incidence of asthma and rhinitis extending into adolescence and early adulthood.
  • High BMI trajectories are associated with reduced pulmonary function and altered exhaled nitric oxide levels.

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