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Updated: Mar 12, 2026

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Treating schizophrenia during menopause.

Amnon Brzezinski1, Noa A Brzezinski-Sinai, Mary V Seeman

  • 11Department of Obstetrics and Gynecology, The Hebrew University-Hadasssah Medical Center, Jerusalem, Israel 2Ben-Gurion University Medical School, Beer-Sheba, Israel 3Department of Psychiatry, University of Toronto, Canada.

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|November 9, 2016
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Summary
This summary is machine-generated.

Hormone therapy (HT) can help women with schizophrenia manage menopausal symptoms and improve cognitive function. However, risks like increased cancer and cardiovascular disease necessitate careful consideration and potential antipsychotic adjustments.

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Area of Science:

  • Psychiatry
  • Endocrinology
  • Women's Health

Background:

  • Schizophrenia affects women differently across their lifespan.
  • Menopause can exacerbate symptoms or alter treatment response in women with schizophrenia.

Purpose of the Study:

  • To review risks and benefits of hormone therapy (HT) for menopausal women with schizophrenia.
  • To determine if antipsychotic regimens require adjustment during menopause.
  • To explore differential responses to HT based on age of schizophrenia onset.

Main Methods:

  • A narrative review of MEDLINE-searched articles (1990-2016).
  • Keywords included schizophrenia, gender, menopause, estrogen, and hormones.
  • 62 relevant articles were selected from 800 abstracts.

Main Results:

  • HT during perimenopause can improve psychotic, cognitive, and affective symptoms in women with schizophrenia.
  • HT also alleviates vasomotor, genitourinary, and sleep symptoms.
  • Potential increased risks of breast cancer and cardiovascular disease exist, requiring individualized assessment alongside antipsychotic side effects.

Conclusions:

  • Hormone therapy and adjusted antipsychotic management should be considered for menopausal women with schizophrenia.
  • Further research is needed to answer whether early- and late-onset schizophrenia respond differently to HT.