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Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics

Liangzhen Zheng1, Valerie Chunling Lin1, Yuguang Mu1

  • 1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

Plos One
|November 9, 2016
PubMed
Summary

Researchers modeled the apo-form progesterone receptor ligand-binding domain (LBD) using simulations. This reveals flexible regions and distinct conformations, crucial for understanding receptor function and drug discovery.

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