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Islet cell transplantation improves nerve conduction velocity in type 1 diabetes compared with intensive medical
Blake Fensom1, Claire Harris1, Sharon E Thompson1
1Department of Medicine, Vancouver General Hospital and University of British Columbia, Canada.
Background:
Neuropathy is a common diabetic complication that can result in significant disability. Few treatment options exist to reverse this process.
Methods:
We conducted a one-way crossover cohort study comparing intensive medical treatment and islet cell transplantation for type 1 diabetes on the change in nerve conduction velocity over six years.
Findings:
For subjects with some neuropathy at baseline (Z score below -1), nerve conduction velocity significantly improved post-transplant (slope (0.073±0.042) while it worsened in medically treated patients (-0.136±0.081) (p<.05).
Interpretation:
Islet cell transplantation improves nerve conduction velocity and could be further investigated as a treatment for neuropathy in type 1 diabetes.
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