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Biological Characteristics of Cluster of Differentiation 147 and Its Relationship with Tumour

Cen Gao1, Chao-Hui Lu1, Jie Chen1

  • 1Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|November 10, 2016
PubMed

Insights

Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer (EMMPRIN), is a key protein on cancer cells. This review explores its structure, functions, and mechanisms in promoting tumor growth and spread.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cluster of differentiation 147 (CD147), or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein.
  • It belongs to the immunoglobulin superfamily and is highly expressed on malignant tumor cells.

Purpose of the Study:

  • This review synthesizes current knowledge on the structural and biological characteristics of CD147.
  • It focuses on the multifaceted roles of CD147 in various cancers and the underlying molecular mechanisms.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of structural and functional data related to CD147.
  • Synthesis of information on CD147's role in cancer progression.

Main Results:

  • CD147 stimulates matrix metalloproteinase production in the tumor microenvironment.
  • It promotes cancer cell growth, invasion, metastasis, glycolysis, angiogenesis, and resistance to multidrugs and anoikis.
  • CD147 also inhibits starvation-induced autophagy.

Conclusions:

  • CD147 plays a critical role in multiple aspects of cancer progression.
  • Understanding CD147's functions and mechanisms is crucial for developing targeted cancer therapies.

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