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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
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Molecularly imprinted polymers for bioanalytical sample preparation.

Mariana Roberto Gama1, Carla Beatriz Grespan Bottoli1

  • 1Institute of Chemistry - State University of Campinas, Unicamp, Brazil.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|November 10, 2016
PubMed
Summary
This summary is machine-generated.

Molecularly imprinted polymers (MIPs) offer high selectivity for bioanalytical sample preparation. This review highlights MIP preparation and their use as sorbent materials in pharmaceutical and biomedical analysis, demonstrating excellent performance in complex matrices.

Keywords:
BioanalysisBiomarkersMetabolitesMolecularly imprinted polymersSorbents

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Molecularly imprinted polymers (MIPs) are synthetic receptors with tailored recognition properties.
  • Their stability and selectivity make them promising for various analytical applications.

Purpose of the Study:

  • To review the preparation of MIPs.
  • To discuss the application of MIPs as sorbent materials in pharmaceutical and biomedical analysis.

Main Methods:

  • Discussion of MIP synthesis incorporating template molecules.
  • Review of different MIP extraction configurations: solid-phase extraction (SPE), solid-phase microextraction (SPME), magnetic SPE, packed sorbent microextraction, and SPE in pipette tips.

Main Results:

  • MIPs exhibit high selectivity and stability for sample preparation.
  • Various MIP-based extraction techniques demonstrate good performance in complex biological and pharmaceutical matrices.

Conclusions:

  • MIPs are effective sorbent materials for sample preparation in bioanalytical methods.
  • Their application is particularly beneficial for analyzing complex matrices prior to bioanalysis.