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Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed1, Lin Luo2, Akhileshwar Namani1

  • 1Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|November 10, 2016
PubMed

Insights

This review highlights the Keap1/Nrf2/ARE pathway

Area of Science:

  • * Molecular Biology and Biochemistry: Focuses on cellular signaling pathways involved in inflammation and disease.
  • * Pharmacology and Drug Discovery: Investigates phytochemicals as potential therapeutic agents.
  • * Immunology: Explores the role of Nrf2 in regulating inflammatory responses.

Background:

  • * Inflammation is a common hallmark of chronic diseases and cancer.
  • * The Keap1/Nrf2/ARE signaling pathway is crucial for regulating anti-inflammatory gene expression.
  • * Nrf2 plays a key role in orchestrating inflammatory cell recruitment and gene expression.

Purpose of the Study:

  • * To review the Keap1/Nrf2/ARE pathway, its downstream genes, and its role in inflammatory diseases.
  • * To explore the crosstalk between Nrf2 and the NF-κB pathway.
  • * To discuss Nrf2's regulation of the NLRP3 inflammasome and the development of Nrf2-activating phytochemicals.

Main Methods:

  • * Literature review of scientific studies on the Keap1/Nrf2/ARE pathway.
  • * Analysis of Nrf2's role in animal models of inflammatory diseases.
  • * Examination of phytochemicals targeting the Nrf2/ARE signaling pathway.

Main Results:

  • * The Keap1/Nrf2/ARE pathway is a key regulator of the anti-inflammatory response.
  • * Nrf2 influences inflammatory disease progression and interacts with other signaling pathways like NF-κB.
  • * Nrf2 modulates NLRP3 inflammasome activity, impacting inflammation.
  • * Various phytochemicals have demonstrated potential in mediating the Nrf2/ARE pathway for anti-inflammatory effects.

Conclusions:

  • * The Keap1/Nrf2/ARE pathway is a critical target for managing inflammation and related diseases.
  • * Phytochemicals modulating Nrf2 present a promising avenue for novel anti-inflammatory drug discovery.
  • * Further research into Nrf2-dependent mechanisms can lead to innovative therapeutic strategies.
Keywords:
AREInflammationKeap1Nrf2Oxidative stressPhytochemical

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