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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
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The interaction between human papillomavirus and other viruses
1Department of Microbiology and Immunology, Center for Tumor and Molecular Virology, and Feist-Weiller Cancer Center. Louisiana State University Health Sciences Center-Shreveport. Shreveport, LA 71103, USA.
Virus Research
|November 10, 2016
Summary
Human papillomavirus (HPV) causes cancer but needs cofactors. This review examines other viruses like HIV and EBV as potential contributors or therapeutic agents in HPV-associated cancers.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- Human papillomavirus (HPV) is a known cause of anogenital and head and neck cancers.
- However, HPV alone is insufficient for carcinogenesis, suggesting the involvement of cofactors.
- Numerous biological and environmental factors influence HPV infection and cancer development.
Purpose of the Study:
- To review epidemiological and experimental studies on viral cofactors in HPV-associated cancers.
- To investigate the role of various viruses (e.g., HIV, HSV, EBV) in HPV carcinogenesis.
- To explore potential therapeutic roles of viral co-infections against HPV-driven tumors.
Main Methods:
- Literature review of epidemiological and experimental research.
- Analysis of studies investigating viral co-infections with HPV.
- Examination of mechanisms linking viral cofactors to HPV persistence and cancer progression.
Main Results:
- Viral co-infections can influence HPV persistence, tumor initiation, and progression.
- Some viral co-infections may enhance HPV-driven carcinogenesis.
- Conversely, certain viral co-infections might possess anti-tumor effects against HPV-associated malignancies.
Conclusions:
- Viral cofactors play a complex role in the development of HPV-associated cancers.
- Understanding these interactions is crucial for developing effective prevention and treatment strategies.
- Further research is needed to elucidate the dual role of viral co-infections as both contributors and potential therapeutics.
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