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Céline Poupeau1, Christel Roland2, Jean-François Bussières3
1est une assistante de recherche, Unité de recherche en pratique pharmaceutique, Centre hospitalier universitaire Sainte-Justine, Montréal, Québec. Elle est aussi une étudiante dans le programme D.Pharm. dans la Faculté des Sciences Pharmaceutiques et Biologiques de Nancy, Université de Nancy 1, Nancy, France.
The Canadian Journal of Hospital Pharmacy
|November 10, 2016
Summary
Hazardous drug traces were found in the urine of 21% of health care professionals in a 2010-2015 review. Some studies detected no antineoplastic drug exposure in workers.
Area of Science:
- Occupational Health
- Toxicology
- Analytical Chemistry
Background:
- Growing evidence indicates hazardous drug traces in healthcare professionals' urine.
- Occupational exposure to antineoplastic drugs is a significant concern in healthcare settings.
Approach:
- Systematic literature review of studies from 2010-2015.
- Searched PubMed and Google Scholar for occupational exposure and antineoplastic agents.
- Included 24 studies involving 826 exposed workers and 175 controls across 7 countries.
Key Points:
- Analyzed 13 hazardous drugs, with cyclophosphamide and platinum-based drugs most frequently monitored.
- Positive urine test results ranged from 0% to 100% across studies.
- Overall, 21% of 809 exposed workers had at least one positive urine sample.
Conclusions:
- Urine monitoring of healthcare professionals exposed to hazardous drugs is feasible.
- While some studies found no drug traces, others indicated significant occupational exposure.
- Further research may refine monitoring protocols and safety measures.